Correlations between APACHE IIScore and Plasma Levels of Cytokines in Postsurgical Patients
نویسنده
چکیده
This study was designed to assess whether plasma cy-tokines correlated with the clinical status of postsurgical patients. Plasma levels of cytokines in 72 patients admitted to the intensive care unit were measured using an Enzyme Linked Immuno Solubent Assay. The clinical status was evaluated with the Acute Physiology Age and Chronic Health Evaluation (APACHE) 11 scoring system. There were significant correlations between the APACHE 11 score and the plasma • @ levels • @of • @ Tumor • @ Necrosis • @ Factor(TNF)ƒ¿ • @and interleukin(IL)-1 • @ ƒÀ.But • @ IL-8 • @ and • @ IL-6 • @ did • @ not • @ correlate • @ with the APACHE II score. Three patients died within postopera-tive • @ 20 • @ days. • @ The • @plasma • @ levels • @ of • @ TNF • @ƒ¿,IL-1,ƒÀ,IL-8 • @ and IL-6 were significantly higher in nonsurvivors than in survivors. There was no significant difference in the APACHE II score • @and • @the • @ plasma • @ levels • @of • @ IL-1ƒÀ,IL-8 • @ and • @IL-6 • @between the survivors with Systemic Inflammatory Response Syndrome (SIRS) and those without SIRS. The survivors without SIRS • @ had • @ a • @ higher • @concentration • @ of • @ TNFƒ¿ • @ than • @those • @with SIRS. The • @results • @ indicate • @ that • @TNF • @ƒ¿ • @ and • @IL-1 • @ ƒÀ • @ correlate • @ well with the severity of illness in the postsurgical patients, whereas IL-8 and IL-6 does not. acute physiology age and chronic health evaluation (APACHE) II score, systemic inflammatory response syndrome (SIRS)
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